omicsbox 3.0 release

OmicsBox 3.0 Release: New Module and Features

Once again we are pleased to announce the latest update of OmicsBox 3.0. The whole BioBam team has worked to bring the new version of the BioBam bioinformatics solution to life. We proudly present the Genetic Variation Module as the highlight of OmicsBox 3.0. This module enables variant calling, filtering, and annotation, as well as the association of genetic variations

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OmicsBox 2.2 Release

We are happy to announce the latest update of OmicsBox 2.2. After several months of intensive work we are finally ready to present the new version of BioBam’s bioinformatics solution. OmicsBox 2.2 comes with new Single Cell and Long Read Data Analysis Features and many other platform improvements. OmicsBox continues improving to become the most efficient, powerful and user-friendly bioinformatics

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Single-Cell Differential Expression Analysis

Tutorial: Single-Cell RNA-Seq Differential Expression Analysis

The differential expression (DE) analysis has been used in bulk RNA-seq analysis for many years. It allows us to statistically measure changes in gene expression levels between different groups. With bulk RNA-seq analysis many cells are sequenced at the same time, so gene expression levels are commonly measured at the tissue level. Thus, the differences between samples and conditions are

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BAM File Quality Control

Transcriptome sequencing (RNA-Seq) produces big amounts of valuable information on all transcribed elements in the genome. With RNA-Seq, researchers can interrogate the transcriptome to profile gene expression, uncover alternative splicing, and identify novel and discard aberrant transcripts and coding variants, among others. The resulting BAM Files are the source of information for all proceeding step

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Long read LongQC

Quality Assessment with LongQC

Specific tools for a new generation of sequencing Third Generation Sequencing (TGS) is getting a notable increase in relevance by surpassing some of the limitations of NGS technologies. In that sense, the main feature of TGS is the capacity to produce much longer reads than NGS. These long reads facilitate the assembly of complex genomes and the study of alternative

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Long Read Transcriptome with SQANTI3

Transcriptome Analysis with SQANTI3

Transcriptome analysis is a challenging bioinformatic problem. In eukaryotic transcriptomes, alternative splicing and alternative polyadenylation are the most complex issues. Genome-wide analysis of alternative splicing has been studied with short-read RNA sequencing for a while. Nevertheless, this technology needs a subsequent assembly, which is difficult to be resolved in ambiguities in complex loci.

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