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Use CloudBlast and CloudInterProScan to perform fast sequence alignments and domain searches against reference datasets of your choice.
Link potential homologs and domains with available functional annotation from up-to-date well-curated databases from UniProt and Gene Ontology consortia.
The Blast2GO methodology allows to flexibly assign most reliable functional labels to novel sequence datasets, taking into account source annotation quality and ontology hierarchies.
Use different enrichment analysis approaches (Fisher Exact Test and GSEA) to identify over and under represented molecular functions.
Identify Reactome and KEGG pathways for any set of sequences, use differential expression data to calculate pathway enrichment (GSEA) and a combined visualization to gain insights with ease.
The OmicsBox Functional Analysis module is a well-known comprehensive bioinformatics tool for the functional annotation.
The well known Blast2GO annotation methodology, first published in 2005, is now part of OmicsBox. Blast2GO is the leading bioinformatics platform for the analysis of novel genomes, internationally recognized by the scientific community with over 7000+ research citations.
This tool allows to identify pathways from multiple pathway databases for any set of sequences. In combination with differential expression data the tool allows to calculate pathway enrichment. A result table allows to filter for enriched pathways with linked, differentially expressed, genes.
Discover how to functionally annotate any type of sequence dataset using multiple annotation strategies with Blast2GO, ranging from maximum fidelity to high-coverage and permissive approaches.
With OmicsBox, typical downstream analysis options, including enrichment analysis, pathway analysis, and popular visualization techniques, are fast and easy to use. The RNA-Seq dataset featured in this webinar involves a non-model organism, specifically a roundworm nematode affecting chickens.
Get familiar with all new Modules and Features with a Free Trial or a Custom Demo.
OmicsBox works out of the box on any standard PC or laptop with Windows, Linux and Mac.
This is the full Gene Ontology annotation workflow using cloud-powered algorithms (Blast, InterProScan, GO Mapping) to get the most complete annotation labels. Detailed statistics of every step are generated to summarize results. Combined graphs for the three categories (Biological Process, Molecular Function and Cellular Component) are generated including the annotations from InterProScan results. The final project contains all the data generated in every step.